THE EFFECT OF LONG-TERM CORTICOTROPHIN TREATMENT ON THE CORTICOSTEROID-BINDING CAPACITY OF TRANSCORTIN

Abstract

SUMMARY In rats consecutive daily doses of corticotrophin significantly reduced the corticosterone-binding capacity of transcortin as measured by the gel filtration method, even after previous removal of the adrenals or ovaries. Treatment with formalin for 14 days produced similar, though slightly lesser, changes.