Author:
PIERREPOINT C. G.,GRIFFITHS K.,GRANT J. K.,STEWART J. S. S.
Abstract
SUMMARY
The metabolism of [7α-3H]pregnenolone and [4-14C]dehydroepiandrosterone by a feminizing Leydig cell tumour from a man has been studied in vitro.
The tumour formed the 3β-sulphoxy derivatives of pregnenolone, 17α-hydropregnenolone and dehydroepiandrosterone.
Carbon-labelled oestradiol-17β and tritiated oestriol were isolated from the tumour indicating that the probable pathway of the formation of oestriol was by way of 16α-hydroxylated steroids not involving DHA or oestradiol.
Subject
Endocrinology,Endocrinology, Diabetes and Metabolism
Cited by
33 articles.
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