NEUTRAL STEROID SULPHATION AND OESTROGEN BIOSYNTHESIS IN VITRO BY A FEMINIZING LEYDIG CELL TUMOUR OF THE TESTIS

Author:

PIERREPOINT C. G.,GRIFFITHS K.,GRANT J. K.,STEWART J. S. S.

Abstract

SUMMARY The metabolism of [7α-3H]pregnenolone and [4-14C]dehydroepiandrosterone by a feminizing Leydig cell tumour from a man has been studied in vitro. The tumour formed the 3β-sulphoxy derivatives of pregnenolone, 17α-hydropregnenolone and dehydroepiandrosterone. Carbon-labelled oestradiol-17β and tritiated oestriol were isolated from the tumour indicating that the probable pathway of the formation of oestriol was by way of 16α-hydroxylated steroids not involving DHA or oestradiol.

Publisher

Bioscientifica

Subject

Endocrinology,Endocrinology, Diabetes and Metabolism

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