MANIFESTATIONS OF ADRENAL CORTICAL CARCINOMA WITH HIGH OESTROGEN EXCRETION

Abstract

SUMMARY A 27-yr.-old woman with adrenal cortical carcinoma excreted large amounts of dehydroepiandrosterone (21–25 mg./day) and oestriol (94 μg./day). The latter may have prevented the development of virilizing features and so added to the difficulty in diagnosis. The clinical features and studies of adrenal steroid metabolism are presented, and the significance of the high levels of urinary dehydroepiandrosterone is discussed.