CHANGES IN PLASMA ALDOSTERONE, CORTISOL, CORTICOSTERONE, AND RENIN CONCENTRATION IN A PATIENT WITH SODIUM-LOSING RENAL DISEASE

Abstract

SUMMARY A woman with recurrent urinary infection, bilateral renal calculi, and an abnormal pattern of plasma proteins was unable to reduce urinary sodium excretion when sodium intake was restricted. When the intake of sodium was reduced depletion developed rapidly, and severe hyponatraemia was associated with increased plasma renin and aldosterone concentrations, and a less marked although definite, increase in plasma corticosterone. Plasma cortisol was unchanged during sodium depletion, although it increased normally after the administration of corticotrophin.