INTERRELATION BETWEEN HUMAN CHORIONIC GONADOTROPHIN INHIBITORY ACTIVITY IN PLASMA AND URINE AND THE RATE OF URINARY GONADOTROPHIN EXCRETION

Abstract

SUMMARY The interrelation of urinary and plasma human chorionic gonadotrophin (HCG) inhibitors and the urinary excretion rate of gonadotrophin was studied in ten physically and mentally retarded young males. It was found that the HCG-inhibitory principles had no effect when assayed against the boys' own urinary gonadotrophins. The excretion rate of urinary gonadotrophin was found to be independent of the presence of urinary or plasma HCG-inhibitors, which in turn were not related to the boys' physical development. Certain similarities between the properties of the plasma and urinary HCG-inhibitor and deproteinized pineal extracts are discussed.