Author:
HUTCHINSON J. S. M.,WORDEN J. M.
Abstract
SUMMARY
The possibility of applying the ovarian ascorbic acid depletion assay or its variants to the measurement of luteinizing hormone in human urine extracts has been investigated.
A 3 hr. i.v. technique proved the most sensitive.
The method had limitations as a clinical assay, namely: a relatively low degree of precision, toxicity of some urinary extracts and the fact that about 20 % of assays were invalid owing to a lack of parallelism.
Two of ten patients with amenorrhoea and raised gonadotrophin levels showed a relative lack of FSH as compared with the International Reference Preparation for human menopausal gonadotrophin.
Subject
Endocrinology,Endocrinology, Diabetes and Metabolism
Cited by
5 articles.
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