Serum interleukin-6 level in unmedicated adults with attention-deficit/hyperactivity disorder – preliminary report-Reference-Cited by-同舟云学术

Serum interleukin-6 level in unmedicated adults with attention-deficit/hyperactivity disorder – preliminary report

Published:2024-07-24 Issue:1 Volume:24 Page:69-73
ISSN:1644-6313
Container-title:Psychiatria i Psychologia Kliniczna
language:
Short-container-title:Psychiatr Psychol Klin

Author:

Rosa Zuzanna¹^ORCID,Woźniak Joanna¹,Jerczyńska Hanna²^ORCID,Kaźmierski Jakub¹^ORCID

Affiliation:

1. Department of Geriatric Psychiatry and Psychotic Disorders, Medical University of Lodz, Łódź, Poland

2. Research Laboratory CoreLab, Medical University of Lodz, Łódź, Poland

Abstract

Aim: The aim of the study was to compare adults suffering from attention-deficit/hyperactivity disorder with healthy controls, in terms of their serum concentrations of inflammatory cytokine interleukin-6. Materials and methods: The diagnosis of attention-deficit/hyperactivity disorder was established during the interview with the clinician on the basis of the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition. A total of 36 participants with attention-deficit/hyperactivity disorder and 28 in the control group were included. The age range was 21–55 years. Individuals with a psychiatric comorbidity, allergy, chronic inflammatory disease, and receiving psychostimulant treatment were excluded. Results: Adults diagnosed with attention-deficit/hyperactivity disorder had higher serum concentrations of interleukin-6 in comparison to healthy controls. Conclusions: The aetiology of attention-deficit/hyperactivity disorder may be influenced by the concentration of inflammatory factors.

Publisher

Medical Communications Sp. z.o.o.

Reference32 articles.

1. Anand D, Colpo GD, Zeni G et al.: Attention-deficit/hyperactivity disorder and inflammation: what does current knowledge tell us? A systematic review. Front Psychiatry 2017; 8: 228.

2. Borovcanin MM, Jovanovic I, Radosavljevic G et al.: Interleukin-6 in schizophrenia – is there a therapeutic relevance? Front Psychiatry 2017; 8: 221.

3. Chang JPC, Mondelli V, Satyanarayanan SK et al.: Cortisol, inflammatory biomarkers and neurotrophins in children and adolescents with attention deficit hyperactivity disorder (ADHD) in Taiwan. Brain Behav Immun 2020; 88: 105–113.

4. Chang SJ, Kuo HC, Chou WJ et al.: Cytokine levels and neuropsychological function among patients with attention-deficit/hyperactivity disorder and atopic diseases. J Pers Med 2022; 12: 1155.

5. Chuang YC, Wang CY, Huang WL et al.: Two meta-analyses of the association between atopic diseases and core symptoms of attention deficit hyperactivity disorder. Sci Rep 2022; 12: 3377.