Engaging in the arts is a health-related behavior that may be influenced by social inequalities. While it is generally accepted that there is a social gradient in arts participation, previous studies of arts engagement in the US have not used comprehensive measures of engagement and often focus on single demographic or socioeconomic predictors of engagement rather than simultaneously testing a range of factors that may be related to one another. Using cross-sectional data from the General Social Survey (GSS) in the US, we examined which demographic, socioeconomic, residential, and health factors were associated with attendance at arts events, participation in arts activities, and membership of creative groups. We combined data from 1993 to 2016 in three analytical samples with a sample size of 8,684 for arts events, 4,372 for arts activities, and 4,268 for creative groups. Data were analysed using logistic regression. More education was associated with increased levels of all types of arts engagement. Parental education demonstrated a similar association. Being female, compared to male, was also consistently associated with higher levels of engagement. Attendance at arts events was lower in participants with lower income and social class, poorer health, and those living in less urban areas. However, these factors were not associated with engagement in arts activities or creative groups. Overall, we found evidence for a social gradient in attendance at arts events, which was not as pronounced in engagement in arts activities or creative groups. Given the many benefits of engagement in the arts for education, health, and wider welfare, our findings demonstrate the importance of identifying factors to reduce barriers to participation in the arts across all groups in society.