Grafting of Hyaluronic Acid to PLDLA, used as coating of the models of PLLA bioresorbable coronary stents

Abstract

Coronary artery disease has been leading cause of death in the world, angioplasty stent implantation is an important strategy in these cases. Studies indicate that biodegradability, immobilization of antiproliferatives and bioactive molecules in stents, are the characteristics of future generations of these devices. Amongst them, hyaluronic acid contributes to decrease of the aggregation and proliferation of cells between artery layers and the implanted device. For this purpose, poly (L-lactic acid) (PLLA) bioresorbable coronary stents with hyaluronic acid (HA) grafting in poly (LD- lactic acid) (PLDLA) were developed. The models were characterized as their thermal properties with Thermogravimetric Analysis (TGA) and Differential Scanning Calorimetric Analysis (DSC), Fourier Transform Infrared Spectrometry (FTIR), Wettability, with study of Contact Angle using Water swelling. PLDLA ADH-modified HA grafting presented more hydrophilic surface characteristics, ideal for coating material of this devices. In conclusion, grafting of hyaluronic acid in the PLDLA matrices confirmed, by technics used at this project. The coating of models of PLLA with PLDLA-HAADH made by dip coating technic.