Abstract
The aim of the work was to develop methods for the prevention of reproductive pathologies using drugs containing nanobiomaterials. This is due to the fact that the physiological functioning of the reproductive organs is rich in the state of the antioxidant defense system, the main active component of which are antioxidants that neutralize the negative effects of free radicals – specific products of cell life and their damage factors.
Work on the development and manufacture of drugs was performed on the basis of the Department of Veterinary Reproductology of the State Biotechnology University (Kharkov) and the Department of Nanocrystalline Materials of the Institute of Scintillation Materials (Kharkov), implementation – in farms of various forms of ownership.
Developed methods for the prevention of reproductive pathologies of animals (normalization of the structure and function of the fetoplacental complex of cows and sheep and increase the development potential of newborn calves and lambs, increase the reproductive capacity of bulls and boars) are based on the use of vitamin and hormonal drugs «Caplaestrol + OV», «Carafest + OV» and «Carafand + OV» containing nanobiomaterial – gadolinium orthovanadate activated by europium, the nanoparticles of which are able to penetrate cells and accumulate in nuclei.
The obtained data allow us to conclude that the use of nanobiomaterials ensures the effectiveness of programs for the prevention of reproductive pathologies of animals. In particular, the method of normalizing the structure and function of the fetoplacental complex of cows and sheep and increase the development potential of newborn calves and lambs provides an increase in placental weight by 23,4-24,3 %, newborn weight – by 18,6-29,6 %, increase in the number of cotyledons by 2,9-3,0 % and the area of the hairy part of the chorion – by 13,3-34,7 %, and the method of increasing the reproductive capacity of bulls and boars allows to increase the volume of ejaculate by 4,2-28,7 %, increase sperm motility by 16,7-28,1 %, sperm concentration – by 4,8-13,6 %, testosterone levels – by 16,8-44,2 % and reduce the number of sperm with morphological abnormalities by 1,6-2,4 %.
Publisher
SE Institute of Grain Crops of National Academy of Agrarian Sciences of Ukraine
Reference30 articles.
1. Vlizlo V., Bashhenko M., Iskra R., Fedoruk R., Zhukors'kyj O., Mezenceva L. Nanotehnologii' ta i'h zastosuvannja u tvarynnyctvi j veterynarnij medy-cyni [Nanotechnologies and their application in animal husbandry and veterinary medicine]. Visnyk agrarnoi' nauky. 2015. Vol. 93, No 11. P. 5-9 (in Ukrainian). https://agrovisnyk.com/index.php/agrovisnyk/article/view/178.
2. Vlizlo V., Fedoruk R., Iskra R. Biologichna dija funkcional'nyh nanomaterialiv u riznyh vydiv tvaryn [Biological action of functional nanomaterials in different species of animals]. Visnyk agrarnoi' nauky. 2018. Vol. 96, No 11. P. 80-86. https://doi.org/10.31073/agrovisnyk201811-11.
3. Donchenko A.S., Shkyl' N.N., Burmystrov V.A. Primenenie preparatov, soderzhashhih nanochasticy metallov, v veterinarii [The use of preparations containing metal nanoparticles in veterinary medicine]. Sibirskij vestnik sel'skohozjajstvennoj nauki. 2019. Vol. 49, No 1. P. 59-67. https://doi.org/10.26898/0370-8799-2019-1-8.
4. Koshevoj V.P., Fedorenko S.Ja., Naumenko S.V., Ivanchenko M.M., Onyshhenko O.V., Besedovs'ka K.S., Pasternak A.M., Gladcinova I.O., Koshevoj V.I., Skljarov P.M., Maljukin Ju.V., Jefimova S.L., Klochkov V.K. Kompleksni preparaty, stvoreni na osnovi nano-biomaterialiv ta i'h vykorystannja u veterynarnij reproduktologii' (metodychni rekomendacii') [Complex preparations based on nano-biomaterials and their use in veterinary reproductive medicine (guidelines)]. Dnipropetrovs'k: Porogy, 2016. 110 p.
5. Koshovyj V.P., Ivanchenko M.M., Skljarov P.M., Cymerman O.O., Naumenko S.V. Veterynarna perynatologija [Veterinary perinatology]. Harkiv: vydavnyctvo Shejninoi' O.V., 2008. 465 p.