Synthesis and in vitro Biological Assessments of Novel Thiazole-Based Thiosemicarbazone Complexes-Reference-Cited by-同舟云学术

Synthesis and in vitro Biological Assessments of Novel Thiazole-Based Thiosemicarbazone Complexes

Published:2024-07-31 Issue:3 Volume:12 Page:1389-1397
ISSN:2148-2446
Container-title:Düzce Üniversitesi Bilim ve Teknoloji Dergisi
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Author:

Nartop Dilek¹^ORCID,Hasanoğlu Özkan Elvan²^ORCID,Öğütçü Hatice³^ORCID,Kurnaz Yetim Nurdan⁴^ORCID

Affiliation:

1. DÜZCE ÜNİVERSİTESİ

2. GAZİ ÜNİVERSİTESİ

3. KIRŞEHİR AHİ EVRAN ÜNİVERSİTESİ

4. KIRKLARELİ ÜNİVERSİTESİ

Abstract

In the present work, novel heterocyclic thiazole-based thiosemicarbazone Ag(I) complexes (Hc1, Hc2, Hc3) were obtained using the template method. The structures of synthesized thiosemicarbazone compounds were determined by some spectroscopic techniques (element analysis, infrared spectra (IR), thermogravimetric analysis (TGA), organic elemental analysis, and magnetic susceptibility measurements). The biological activities of novel heterocyclic thiazole-based thiosemicarbazone Ag(I) complexes werev screenedv in vitro against selected disease-causing pathogens (Micrococcus luteus ATCC9341, Staphylococcus epidermidis ATCC12228, Bacillus cereus RSKK863, Pseudomonas aeroginosa ATCC27853, Klebsiella pneumonia ATCC27853, Enterobacter aerogenes ATCC51342, Salmonellav typhi H NCTC9018394, Shigella dysenteria NCTC2966, Proteus vulgaris RSKK96026, Candidav albicans Y-1200-NIH) were as potential antimicrobial agents. It was determined that the thiazole-based thiosemicarbazone Ag(I) complexes exhibited high or moderate antibacterial and antifungal activity.

Publisher

Duzce Universitesi Bilim ve Teknoloji Dergisi

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