Effects of Paracetamol on the Development of Zebrafish (Danio rerio)
-
Published:2023-10-31
Issue:4
Volume:46
Page:1173-1188
-
ISSN:2231-8542
-
Container-title:Pertanika Journal of Tropical Agricultural Science
-
language:en
-
Short-container-title:JTAS
Author:
Asmoning Dewanti Ajeng Istyorini,Kunjirika Tony Prince,Ayu Dewayani Putri Raden Roro Risang,Adaninggar Ascarti,Puji Raharjeng Anita Restu,Retnoaji Bambang,Nuriliani Ardaning,Sofyantoro Fajar,Septriani Nur Indah,T. S. S. G. Saragih Hendry
Abstract
The misuse of paracetamol is becoming more prevalent worldwide. Due to non-compliance with recommended dosage and regulations, paracetamol consumption can result in serious health issues such as liver necrosis, kidney damage, heart damage, and hematological changes. This study sought to investigate the impact of paracetamol on the development of zebrafish embryos, which are often used as a model for assessing the effect of drug exposure on animals. The results indicated that paracetamol negatively affects the hatching and survival rates of zebrafish. Additionally, paracetamol exposure caused spinal abnormalities, pericardial edema, hypopigmentation, reduced heart rate, and spontaneous movement in zebrafish larvae. The developmental abnormalities in zebrafish were more significant with higher concentrations and longer exposure times. These findings may provide valuable insights into the detrimental impact of paracetamol on aquatic animals.
Publisher
Universiti Putra Malaysia
Subject
Plant Science,Forestry
Reference45 articles.
1. Alchin, J., Dhar, A., Siddiqui, K., & Christo, P. J. (2022). Why paracetamol (acetaminophen) is a suitable first choice for treating mild to moderate acute pain in adults with liver, kidney, or cardiovascular disease, gastrointestinal; disorders, asthma, or who are older? Current Medical Research and Opinion, 38(5), 811-825. https://doi.org/10.1080/03007995.2022.2049551 2. Al-Kaf, A. G., Naji, K. M., Abdullah, Q. Y. M., & Edrees, W. H. A. (2017). Occurrence of paracetamol in aquatic environments and transformation by microorganisms: A review. Chronicles of Pharmaceutical Science, 1(6), 341-355. 3. Arias-Alpizar, G., Bussmann, J., & Campbell, F. (2021). Zebrafish embryos as a predictive animal model to study nanoparticle behavior in vivo. Bio-protocol, 11(19), e4173. https://doi.org/10.21769/BioProtoc.4173 4. Bastiaan Vliegenthart, A. D., Antonie, D. J., & Dear, J. W. (2015). Target biomarker profile for the clinical management of paracetamol overdose. British Journal of Clinical Pharmacology, 80(3), 351-362. https://doi.org/10.1111/bcp.12699 5. Cedron, V. P., Wiener, A. M. J., Vera, M., & Sanchez, L. (2020). Acetaminophen affects the survival, pigmentation, and development of craniofacial structures in zebrafish (Danio rerio) embryos. Biochemical Pharmacology, 174, 113816. https://doi.org/10.1016/j.bcp.2020.113816
|
|