Histamine-regulated brain-derived neurotrophic factor (BDNF) catabolism by specific gut microbiota in mice

Abstract

Huangjiu usually causes excessive intoxication. Although the primary components, including β-benzyl ethanol, isopentanol, histamine, and phenethylamine are linked to intoxication, the underlying mechanism remains obscure. The present work thus analysed the effects of oral treatment of these components, particularly histamine, and discovered which of these components induced oxidative stress and inflammatory cytokine responses in mice serum and cerebrum. Lipopolysaccharide levels were elevated, and the gut microbiota was recomposed. Additionally, the catabolic pathway of the brain-derived neurotrophic factor was investigated. The correlation analysis revealed a possible correlation between gut microbiota changes and neurotransmitter imbalance. Based on the findings, histamine might alter the gut microbiota composition, affect the inflammatory LPS accumulation, and modulate the gut-brain axis, thus leading to an increase in oxidative stress, inflammatory response, and neurotransmitter imbalance in the brain. The present work provided a baseline for future research into the effects of Huangjiu, and enhanced our understanding of treating and preventing associated inflammatory diseases.