1. Microvascular Research Laboratories, School of Physiology and Pharmacology, University of Bristol, Bristol, United Kingdom
2. Nuffield Department of Clinical Medicine, Structural Genomics Consortium and Target Discovery Institute (TDI), University of Oxford, Oxford, United Kingdom
3. School of Chemistry, University of Bristol, Bristol, United Kingdom
4. Cardiovascular Research Laboratories, School of Physiology and Pharmacology, University of Bristol, Bristol, United Kingdom
5. Department of Anatomy and Developmental Biology Graduate School of Medicine, Kyoto University, Japan
6. School of Clinical Sciences and School of Cellular and Molecular Medicine, University of Bristol, Bristol, United Kingdom
7. Microvascular Research Laboratories, School of Physiology and Pharmacology, University of Bristol, Bristol, United Kingdom 7Cancer Biology, Division of Oncology, School of Medicine, University of Nottingham, Queen's Medical Centre, Nottingham, United King