Histologic Cell Shape Descriptors for the Retinal Pigment Epithelium in Age-Related Macular Degeneration: A Comparison to Unaffected Eyes

Author:

von der Emde Leon1,Vaisband Marc23,Hasenauer Jan24,Bourauel Leonie1,Bermond Katharina5,Saßmannshausen Marlene1,Heintzmann Rainer67,Holz Frank G.1,Curcio Christine A.8,Sloan Kenneth R.8,Ach Thomas1

Affiliation:

1. Department of Ophthalmology, University Hospital Bonn, Bonn, Germany

2. University of Bonn, Life & Medical Sciences Institute, Bonn, Germany

3. Department of Internal Medicine III with Haematology, Medical Oncology, Haemostaseology, Infectiology and Rheumatology, Oncologic Center; Salzburg Cancer Research Institute–Laboratory for Immunological and Molecular Cancer Research (SCRI-LIMCR); Paracelsus Medical University, Salzburg, Austria, Cancer Cluster Salzburg, Austria

4. Helmholtz Center Munich- German Research Center for Environmental Health, Institute of Computational Biology, Neuherberg, Germany

5. Department of Ophthalmology, Ludwigshafen Hospital, Ludwigshafen, Germany

6. Leibniz Institute of Photonic Technology, Jena, Germany

7. Institute of Physical Chemistry and Abbe Center of Photonics, Friedrich-Schiller University Jena, Jena, Germany

8. Department of Ophthalmology and Visual Sciences, University of Alabama at Birmingham, AL, USA

Publisher

Association for Research in Vision and Ophthalmology (ARVO)

Subject

Ophthalmology,Biomedical Engineering

Reference44 articles.

1. Quantitative autofluorescence and cell density maps of the human retinal pigment epithelium;Ach;Invest Ophthalmol Vis Sci,2014

2. The cytoskeleton of the retinal pigment epithelium: from normal aging to age-related macular degeneration;Tarau;Int J Mol Sci,2019

3. Aging of the human photoreceptor mosaic: evidence for selective vulnerability of rods in central retina;Curcio;Invest Ophthalmol Vis Sci,1993

4. Retinal pigment epithelial cell multinucleation in the aging eye—a mechanism to repair damage and maintain homoeostasis;Chen;Aging Cell,2016

5. RPE cell and sheet properties in normal and diseased eyes;Rashid;Adv Exp Med Biol,2016

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