Pentosan Polysulfate Sodium Causes Diminished Function and Subtle Morphological Changes in Retina and RPE of Mice

Author:

Girardot Preston E.12,Zhang Xian13,Zhang Nan14,Donaldson Kevin J.15,Chrenek Micah A.1,Sellers Jana T.1,Feola Andrew J.126,Papania Jack1,Nickerson John M.1,Jain Nieraj1,Boatright Jeffrey H.12

Affiliation:

1. Department of Ophthalmology, Emory University, Atlanta, GA, United States

2. Center for Visual and Neurocognitive Rehabilitation, Atlanta VA Medical Center, Decatur, GA, United States

3. Department of Ophthalmology, Second Xiangya Hospital, Central South University, Changsha, China

4. Department of Ophthalmology, Zhongnan Hospital of Wuhan University, Wuhan, China

5. Neuroscience Institute, Georgia State University, Atlanta, GA, United States

6. Department of Biomedical Engineering, Georgia Institute of Technology/Emory University, Atlanta, GA, United States

Publisher

Association for Research in Vision and Ophthalmology (ARVO)

Reference33 articles.

1. More evidence linking common bladder medication to a vision-threatening eye condition: new study shows about a quarter of patients with significant exposure to the drug show signs of retinal damage;American Academy of Ophthalmology;ScienceDaily,2019

2. A systematic review of therapeutic approaches used in experimental models of interstitial cystitis/bladder pain syndrome;Kuret;Biomedicines,2021

3. The therapeutic role of sulfated polysaccharides in the urinary bladder;Parsons;Urol Clin North Am,1994

4. Pigmentary maculopathy associated with chronic exposure to pentosan polysulfate sodium;Pearce;Ophthalmology,2018

5. Chloroquine causes lysosomal dysfunction in neural retina and RPE: implications for retinopathy;Mahon;Curr Eye Res,2004

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