1. From the Department of Physiology, University of Melbourne, Parkville, Victoria, Australia;
2. Department of Medicine, St Vincent’s Hospital, University of Melbourne, Fitzroy, Australia;
3. GlaxoSmithKline Pharmaceuticals, King of Prussia, Pennsylvania; and
4. Department of Medicine, St Vincent’s Hospital, University of Melbourne, Fitzroy, Australia;4Department of Medicine, University of Toronto, St. Michael’s Hospital, Toronto, Canada.