AAV Gene Augmentation of Truncated Complement Factor H Differentially Rescues Ocular Complement Dysregulation in a Mouse Model

Author:

Grigsby Daniel1,Klingeborn Mikael12,Kelly Una1,Chew Lindsey A.13,Asokan Aravind4,Devlin Garth4,Smith Sharon5,Keyes Lisa6,Timmers Adrian7,Scaria Abraham5,Bowes Rickman Catherine13

Affiliation:

1. Department of Ophthalmology, Duke University School of Medicine, Durham, North Carolina, United States

2. McLaughlin Research Institute, Great Falls, Montana, United States

3. Department of Cell Biology, Duke University School of Medicine, Durham, North Carolina, United States

4. Departments of Surgery, Molecular Genetics and Microbiology, and Biomedical Engineering, Duke University School of Medicine, Durham, North Carolina, United States

5. Applied Genetic Technologies Corporation, Alachua, Florida, United States

6. Pfizer, Morrisville, North Carolina, United States

7. Editas Medicine, Cambridge, Massachusetts, United States

Publisher

Association for Research in Vision and Ophthalmology (ARVO)

Subject

Cardiology and Cardiovascular Medicine

Cited by 3 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. CFH Haploinsufficiency and Complement Alterations in Early-Onset Macular Degeneration;Investigative Ophthalmology & Visual Science;2024-04-29

2. Gliosis-dependent expression of complement factor H truncated variants attenuates retinal neurodegeneration following ischemic injury;Journal of Neuroinflammation;2024-02-22

3. Choriocapillaris;Reference Module in Neuroscience and Biobehavioral Psychology;2024

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