Selective BD2 Inhibitor Exerts Anti-Fibrotic Effects via BRD4/FoxM1/Plk1 Axis in Orbital Fibroblasts From Patients With Thyroid Eye Disease

Author:

Xie Yanyan1,Pan Yuan1,Chen Qian1,Chen Yuxi1,Chen Guanyu1,Wang Mei2,Zeng Peng2,Li Zhuang1,Li Zuoyi1,Wang Sha345,Yang Huasheng1,Liang Dan1

Affiliation:

1. Department of Ocular Immunology, State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangzhou, China

2. Department of Ophthalmology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China

3. National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China

4. Eye Center of Xiangya Hospital, Central South University, Changsha, China

5. Hunan Key Laboratory of Ophthalmology, Changsha, China

Publisher

Association for Research in Vision and Ophthalmology (ARVO)

Subject

General Medicine

Reference51 articles.

1. Pathogenesis of Graves ophthalmopathy: implications for prediction, prevention, and treatment;Garrity;Am J Ophthalmol,2006

2. Rituximab for thyroid-associated ophthalmopathy;Kang;Cochrane Database Syst Rev,2022

3. Advances in treatment of active, moderate-to-severe Graves' ophthalmopathy;Wiersinga;Lancet Diabetes Endocrinol,2017

4. Advances in the pharmacological treatment of Graves' orbitopathy;Ruchala;Expert Rev Clin Pharmacol,2016

5. Surgical orbital decompression for thyroid eye disease;Boboridis;Cochrane Database Syst Rev,2011

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