Author:
Abbas Albaayit Shaymaa Fadhel
Abstract
Zerumbone (ZER) is a well-known sesquiterpene composite can be set up in the rhizomes of Zingiber zerumbet (Smith), having anti-cancer, anti-inflammatory and anti-hyperglycemic effects. This study aimed to investigate the inhibitory potential of ZER against drug-target enzymes involved in human pathologies, namely, obesity (Pancreatic lipase) and idiopathic intracranial hypertension (carbonic anhydrase). Result: ZER inhibits pancreatic lipase and carbonic anhydrase at percentages of 52.5 and 71.3% with 184.1±5 and 69.3±0.43 μg/mL IC50 values, respectively. Consequently, ZER has an excellent inhibitory action against pancreatic lipase and carbonic anhydrase, making it interesting anti-obesity drug candidate and avert patho-physiological-related carbonic anhydrase
Publisher
Pakistan Journal of Agricultural Sciences
Subject
Plant Science,Soil Science,Agronomy and Crop Science,Food Science
Cited by
7 articles.
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