Aurora A kinase activation: Different means to different ends-Reference-Cited by-同舟云学术

Aurora A kinase activation: Different means to different ends

Published:2021-07-21 Issue:9 Volume:220 Page:
ISSN:0021-9525
Container-title:Journal of Cell Biology
language:en
Short-container-title:

Author:

Tavernier Nicolas¹,Sicheri Frank²³⁴,Pintard Lionel¹^ORCID

Affiliation:

1. Programme équipe Labellisée Ligue Contre le Cancer - Université de Paris, Centre National de la Recherche Scientifique, Institut Jacques Monod, Paris, France

2. Centre for Systems Biology, Lunenfeld Tanenbaum Research Institute, Sinai Health System, Toronto, Canada

3. Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada

4. Department of Biochemistry, University of Toronto, Toronto, ON, Canada

Abstract

Aurora A is a serine/threonine kinase essential for mitotic entry and spindle assembly. Recent molecular studies have revealed the existence of multiple, distinct mechanisms of Aurora A activation, each occurring at specific subcellular locations, optimized for cellular context, and primed by signaling events including phosphorylation and oxidation.

Funder

Canadian Cancer Society

Canadian Cancer Society Research Institute

Canadian Institutes of Health Research

Terry Fox Research Institute

Agence Nationale de la Recherche

Ligue Contre le Cancer

Programme équipe Labellisée

Publisher

Rockefeller University Press

Subject

Cell Biology