Programmed cortical ER collapse drives selective ER degradation and inheritance in yeast meiosis

Author:

Otto George Maxwell1ORCID,Cheunkarndee Tia1ORCID,Leslie Jessica Mae1,Brar Gloria Ann123ORCID

Affiliation:

1. Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA

2. California Institute for Quantitative Biosciences, University of California, Berkeley, Berkeley, CA

3. Center for Computational Biology, University of California, Berkeley, Berkeley, CA

Abstract

The endoplasmic reticulum (ER) carries out essential and conserved cellular functions, which depend on the maintenance of its structure and subcellular distribution. Here, we report developmentally regulated changes in ER morphology and composition during budding yeast meiosis, a conserved differentiation program that gives rise to gametes. A subset of the cortical ER collapses away from the plasma membrane at anaphase II, thus separating into a spatially distinct compartment. This programmed collapse depends on the transcription factor Ndt80, conserved ER membrane structuring proteins Lnp1 and reticulons, and the actin cytoskeleton. A subset of ER is retained at the mother cell plasma membrane and excluded from gamete cells via the action of ER–plasma membrane tethering proteins. ER remodeling is coupled to ER degradation by selective autophagy, which relies on ER collapse and is regulated by timed expression of the autophagy receptor Atg40. Thus, developmentally programmed changes in ER morphology determine the selective degradation or inheritance of ER subdomains by gametes.

Funder

Rose Hills Foundation

National Institutes of Health

Publisher

Rockefeller University Press

Subject

Cell Biology

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