WASP stings into matrix to lead immune cell migration-Reference-Cited by-同舟云学术

WASP stings into matrix to lead immune cell migration

Published:2022-01-21 Issue:2 Volume:221 Page:
ISSN:0021-9525
Container-title:Journal of Cell Biology
language:en
Short-container-title:

Author:

Rottner Klemens¹²^ORCID,Stradal Theresia E.B.²^ORCID

Affiliation:

1. Division of Molecular Cell Biology, Zoological Institute, Technische Universität Braunschweig, Braunschweig, Germany

2. Department of Cell Biology, Helmholtz Centre for Infection Research, Braunschweig, Germany

Abstract

WASP is a remodeler of the actin cytoskeleton, but its mechanistic contribution to neutrophil migration is unclear. In this issue, Brunetti et al. (2021. J. Cell Biol.https://doi.org/10.1083/jcb.202104046) show that WASP is recruited to substrate-induced membrane deformations near the cell front, where it induces Arp2/3 complex–mediated local actin assembly to direct migration.

Publisher

Rockefeller University Press

Subject

Cell Biology

Link

https://rupress.org/jcb/article-pdf/doi/10.1083/jcb.202112087/1427948/jcb_202112087.pdf

Reference10 articles.

1. Actin assembly mechanisms at a glance

2. Nucleation, stabilization, and disassembly of branched actin networks

3. Force Feedback Controls Motor Activity and Mechanical Properties of Self-Assembling Branched Actin Networks

4. The cell pushes back: The Arp2/3 complex is a key orchestrator of cellular responses to environmental forces

5. Cellular functions of WASP family proteins at a glance

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