A firehose for phospholipids-Reference-Cited by-同舟云学术

A firehose for phospholipids

Published:2020-04-27 Issue:5 Volume:219 Page:
ISSN:0021-9525
Container-title:Journal of Cell Biology
language:en
Short-container-title:

Author:

Prinz William A.¹^ORCID,Hurley James H.²³^ORCID

Affiliation:

1. National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD

2. Department of Molecular and Cell Biology and California Institute for Quantitative Biosciences, University of California, Berkeley, Berkeley, CA

3. Molecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, Berkeley, CA

Abstract

All lipid transport proteins in eukaryotes are thought to shuttle lipids between cellular membranes. In this issue, Li et al. (2020. J. Cell Biol.https://doi.org/10.1083/jcb.202001161) show that Vps13 has a channel-like domain that may allow lipids to flow between closely apposed membranes at contact sites.

Funder

National Institutes of Health

Human Frontier Science Program

Publisher

Rockefeller University Press

Subject

Cell Biology

Link

http://rupress.org/jcb/article-pdf/doi/10.1083/jcb.202003132/1382332/jcb_202003132.pdf

Reference9 articles.

1. Cryo-EM reconstruction of a VPS13 fragment reveals a long groove to channel lipids between membranes

2. The autophagic membrane tether ATG2A transfers lipids between membranes