Affiliation:
1. Microscopy Core Facility and Department of Cellular Microbiology, Max Planck Institute for Infection Biology, 10117 Berlin, Germany
Abstract
Neutrophil extracellular traps (NETs) are made of processed chromatin bound to granular and selected cytoplasmic proteins. NETs are released by white blood cells called neutrophils, maybe as a last resort, to control microbial infections. This release of chromatin is the result of a unique form of cell death, dubbed “NETosis.” Here we review our understanding of how NETs are made, their function in infections and as danger signals, and their emerging importance in autoimmunity and coagulation.
Publisher
Rockefeller University Press
Cited by
815 articles.
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