DNA-dependent protein kinase in nonhomologous end joining: a lock with multiple keys?-Reference-Cited by-同舟云学术

DNA-dependent protein kinase in nonhomologous end joining: a lock with multiple keys?

Published:2007-10-15 Issue:2 Volume:179 Page:183-186
ISSN:1540-8140
Container-title:Journal of Cell Biology
language:en
Short-container-title:

Author:

Weterings Eric¹,Chen David J.¹

Affiliation:

1. Division of Molecular Radiation Biology, Department of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, TX 75390

Abstract

The DNA-dependent protein kinase (DNA-PK) is one of the central enzymes involved in DNA double-strand break (DSB) repair. It facilitates proper alignment of the two ends of the broken DNA molecule and coordinates access of other factors to the repair complex. We discuss the latest findings on DNA-PK phosphorylation and offer a working model for the regulation of DNA-PK during DSB repair.

Publisher

Rockefeller University Press

Subject

Cell Biology

Link

http://rupress.org/jcb/article-pdf/179/2/183/1333706/jcb_200705106.pdf

Reference23 articles.

1. XLF Interacts with the XRCC4-DNA Ligase IV Complex to Promote DNA Nonhomologous End-Joining

2. Autophosphorylation-dependent remodeling of the DNA-dependent protein kinase catalytic subunit regulates ligation of DNA ends

3. Role of DNA–PK in the cellular response to DNA double-strand breaks

4. Autophosphorylation of the DNA-dependent protein kinase catalytic subunit is required for rejoining of DNA double-strand breaks

5. Cell Cycle Dependence of DNA-dependent Protein Kinase Phosphorylation in Response to DNA Double Strand Breaks

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