Affiliation:
1. Department of Medical Oncology, University Medical Center Groningen, University of Groningen, 9723GZ Groningen, Netherlands
Abstract
Phosphoglycerate mutase 1 (PGAM1) functions in glycolysis. In this issue, Qu et al. (2017. J. Cell Biol. https://doi.org/10.1083/jcb.201607008) show that PGAM1 inactivation leads to nucleotide depletion, which causes defective homologous recombination–mediated DNA repair, suggesting that targeting metabolic enzymes increases cancer cell susceptibility to DNA damaging agents.
Funder
KWF Kankerbestrijding
Netherlands Organisation for Scientific Research
H2020 European Research Council
Publisher
Rockefeller University Press
Cited by
10 articles.
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