The heat shock factor HSF1 juggles protein quality control and metabolic regulation-Reference-Cited by-同舟云学术

The heat shock factor HSF1 juggles protein quality control and metabolic regulation

Published:2017-02-09 Issue:3 Volume:216 Page:551-553
ISSN:0021-9525
Container-title:Journal of Cell Biology
language:en
Short-container-title:

Author:

Cantó Carles¹²^ORCID

Affiliation:

1. Nestlé Institute of Health Sciences, Lausanne CH-1015, Switzerland

2. School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne CH-1015, Switzerland

Abstract

Transcriptional regulators often act as central hubs to integrate multiple nutrient and stress signals. In this issue, Qiao et al. (2017. J. Cell Biol. https://doi.org/10.1083/jcb.201607091) demonstrate how heat shock factor 1 (HSF1) uncouples metabolic control from proteostatic regulation and unveils HSF1 as a critical transcriptional regulator of NAD+ metabolism.

Publisher

Rockefeller University Press

Subject

Cell Biology

Link

http://rupress.org/jcb/article-pdf/216/3/551/1375044/jcb_201701093.pdf

Reference10 articles.

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2. HSF-1–mediated cytoskeletal integrity determines thermotolerance and life span;Baird;Science.,2014

3. NAD+ metabolism and the control of energy homeostasis: A balancing act between mitochondria and the nucleus;Cantó;Cell Metab.,2015

4. Suppression of the HSF1-mediated proteotoxic stress response by the metabolic stress sensor AMPK;Dai;EMBO J.,2015

5. Heterotypic signals from neural HSF-1 separate thermotolerance from longevity;Douglas;Cell Reports.,2015

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