Human Myoblast Fusion Requires Expression of Functional Inward Rectifier Kir2.1 Channels-Reference-Cited by-同舟云学术

Human Myoblast Fusion Requires Expression of Functional Inward Rectifier Kir2.1 Channels

Published:2001-05-07 Issue:4 Volume:153 Page:677-686
ISSN:0021-9525
Container-title:Journal of Cell Biology
language:en
Short-container-title:

Author:

Fischer-Lougheed Jacqueline¹,Liu Jian-Hui¹²,Espinos Estelle¹,Mordasini David¹,Bader Charles R.²,Belin Dominique³,Bernheim Laurent¹

Affiliation:

1. Département de Physiologie et, Centre Médical Universitaire, CH-1211 Geneva 4, Switzerland

2. Division de Recherche Clinique Neuro-Musculaire, Département des Neurosciences Cliniques et Dermatologie, Hôpital Cantonal Universitaire, 24 rue Micheli-du-Crest, 1211 Geneva 14, Switzerland

3. Département de Pathologie, Centre Médical Universitaire, CH-1211 Geneva 4, Switzerland

Abstract

Myoblast fusion is essential to skeletal muscle development and repair. We have demonstrated previously that human myoblasts hyperpolarize, before fusion, through the sequential expression of two K+ channels: an ether-à-go-go and an inward rectifier. This hyperpolarization is a prerequisite for fusion, as it sets the resting membrane potential in a range at which Ca2+ can enter myoblasts and thereby trigger fusion via a window current through α1H T channels.

Publisher

Rockefeller University Press

Subject

Cell Biology

Link

http://rupress.org/jcb/article-pdf/153/4/677/1298785/0102021.pdf

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5. An ether-a-go-go K+ current, Ih-eag, contributes to the hyperpolarization of human fusion-competent myoblasts;Bijlenga;J. Physiol.,1998

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