1. Department of Physiology, McGill University, Montreal, Quebec, Canada H3G1Y6; Centre for Research in Neuroscience, McGill University, Montreal General Hospital Research Institute, Montreal, Quebec, Canada H3G 1A4; Department of Pathology, Robert Wood Johnson Medical School, Piscataway, New Jersey 08854; and MRIC Biotechnology Group, The North East Wales Institute, Plas Coch, Mold Road, Wrexam, Un