Sonic Hedgehog Opposes Epithelial Cell Cycle Arrest-Reference-Cited by-同舟云学术

Sonic Hedgehog Opposes Epithelial Cell Cycle Arrest

Published:1999-10-04 Issue:1 Volume:147 Page:71-76
ISSN:0021-9525
Container-title:Journal of Cell Biology
language:en
Short-container-title:

Author:

Fan Hongran¹²,Khavari Paul A.¹³

Affiliation:

1. VA Palo Alto Health Care System, Palo Alto, California 94304

2. Department of Dermatology, Stanford University School of Medicine, Stanford, California 94305

3. Department of Molecular Pharmacology, Stanford University School of Medicine, Stanford, California 94305

Abstract

Stratified epithelium displays an equilibrium between proliferation and cell cycle arrest, a balance that is disrupted in basal cell carcinoma (BCC). Sonic hedgehog (Shh) pathway activation appears sufficient to induce BCC, however, the way it does so is unknown. Shh-induced epidermal hyperplasia is accompanied by continued cell proliferation in normally growth arrested suprabasal cells in vivo. Shh-expressing cells fail to exit S and G2/M phases in response to calcium-induced differentiation and also resist exhaustion of replicative growth capacity. In addition, Shh blocks p21CIP1/WAF1-induced growth arrest. These data indicate that Shh promotes neoplasia by opposing normal stimuli for epithelial cell cycle arrest.

Publisher

Rockefeller University Press

Subject

Cell Biology

Link

http://rupress.org/jcb/article-pdf/147/1/71/1287408/9907037.pdf

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