MT1-MMP: Endosomal delivery drives breast cancer metastasis-Reference-Cited by-同舟云学术

MT1-MMP: Endosomal delivery drives breast cancer metastasis

Published:2015-10-26 Issue:2 Volume:211 Page:215-217
ISSN:0021-9525
Container-title:Journal of Cell Biology
language:en
Short-container-title:

Author:

Linder Stefan¹

Affiliation:

1. Institute for Medical Microbiology, Virology, and Hygiene, University Medical Center Eppendorf, 20246 Hamburg, Germany

Abstract

The membrane-tethered membrane type 1–matrix metalloproteinase (MT1-MMP) mediates proteolysis-based invasive tumor growth. In this issue, Marchesin et al. (2015. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201506002) describe a tug-of-war mechanism regulating dynein and kinesin motors to drive endosome tubulation and MT1-MMP delivery to the surface of cancer cells, identifying a crucial regulatory axis for tumor metastasis.

Publisher

Rockefeller University Press

Subject

Cell Biology

Link

http://rupress.org/jcb/article-pdf/211/2/215/1370511/jcb_201510009.pdf

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