Affiliation:
1. Program of Tissue and Organ Homeostasis, Centro de Biología Molecular “Severo Ochoa,” Consejo Superior de Investigaciones Científicas-Universidad Autóonama de Madrid, Madrid, Spain 1
Abstract
Epithelial cell morphology is essential for cellular homeostasis, but the mechanisms by which cell shape is established remain unclear. In this study, Marivin et al. (2022. J. Cell Biol.https://doi.org/10.1083/jcb.202111002) identify DAPLE as a linker between polarity complexes and the actomyosin network at apical junctions. By recruiting CD2P and activating Gαβγ-mediated RhoA signaling, DAPLE ensures proper cell shape and function.
Funder
Ministerio de Ciencia e Innovación
Fondos FEDER investigación
Fundación Ramon Areces
Consejo Superior de Investigaciones Científicas
Publisher
Rockefeller University Press