Mitochondrial lipid transport and biosynthesis: A complex balance

Author:

Mesmin Bruno12

Affiliation:

1. Institut de Pharmacologie Moléculaire et Cellulaire, Université de Nice Sophia-Antipolis, 06560 Valbonne, France

2. Centre National de la Recherche Scientifique, 06560 Valbonne, France

Abstract

Little is known about how mitochondrial lipids reach inner membrane–localized metabolic enzymes for phosphatidylethanolamine synthesis. Aaltonen et al. (2016. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201602007) and Miyata et al. (2016. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201601082) now report roles for two mitochondrial complexes, Ups2–Mdm35 and mitochondrial contact site and cristae organizing system, in the biosynthesis and transport of mitochondrial lipids.

Funder

Institut National de la Santé et de la Recherche Médicale

Publisher

Rockefeller University Press

Subject

Cell Biology

Reference19 articles.

1. MICOS and phospholipid transfer by Ups2–Mdm35 organize membrane lipid synthesis in mitochondria;Aaltonen;J. Cell Biol.,2016

2. Conserved SMP domains of the ERMES complex bind phospholipids and mediate tether assembly;AhYoung;Proc. Natl. Acad. Sci. USA.,2015

3. Phosphatidylethanolamine and cardiolipin differentially affect the stability of mitochondrial respiratory chain supercomplexes;Böttinger;J. Mol. Biol.,2012

4. PI4P/phosphatidylserine countertransport at ORP5- and ORP8-mediated ER–plasma membrane contacts;Chung;Science.,2015

5. Cloning of a gene (PSD1) encoding phosphatidylserine decarboxylase from Saccharomyces cerevisiae by complementation of an Escherichia coli mutant;Clancey;J. Biol. Chem.,1993

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