Lysosomes relax in the cellular suburbs-Reference-Cited by-同舟云学术

Lysosomes relax in the cellular suburbs

Published:2016-03-14 Issue:6 Volume:212 Page:617-619
ISSN:0021-9525
Container-title:Journal of Cell Biology
language:en
Short-container-title:

Author:

Gowrishankar Swetha¹²,Ferguson Shawn M.¹²

Affiliation:

1. Department of Cell Biology, Yale University School of Medicine, New Haven, CT 06510

2. Program in Cellular Neuroscience, Neurodegeneration and Repair, Yale University School of Medicine, New Haven, CT 06510

Abstract

Lysosomes support cellular homeostasis by degrading macromolecules and recycling nutrients. In this issue, Johnson et al. (2016. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201507112) reveal a heterogeneity in lysosomal pH and degradative ability that correlates with lysosome subcellular localization, raising questions about the functional implications and mechanisms underlying these observations.

Funder

National Institutes of Health

Publisher

Rockefeller University Press

Subject

Cell Biology

Link

http://rupress.org/jcb/article-pdf/212/6/617/1261941/jcb_201602082.pdf

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3. RILP regulates vacuolar ATPase through interaction with the V1G1 subunit;De Luca;J. Cell Sci.,2014