Affiliation:
1. Molecular and Cell Biophysics Lab, University of Pennsylvania, Philadelphia, PA 19104
Abstract
The nucleus is linked mechanically to the extracellular matrix via multiple polymers that transmit forces to the nuclear envelope and into the nuclear interior. Here, we review some of the emerging mechanisms of nuclear mechanosensing, which range from changes in protein conformation and transcription factor localization to chromosome reorganization and membrane dilation up to rupture. Nuclear mechanosensing encompasses biophysically complex pathways that often converge on the main structural proteins of the nucleus, the lamins. We also perform meta-analyses of public transcriptomics and proteomics data, which indicate that some of the mechanosensing pathways relaying signals from the collagen matrix to the nucleus apply to a broad range of species, tissues, and diseases.
Funder
National Institutes of Health
National Cancer Institute
National Heart, Lung, and Blood Institute
American Heart Association
National Science Foundation
Publisher
Rockefeller University Press
Cited by
287 articles.
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