Why proteomics is not the new genomics and the future of mass spectrometry in cell biology-Reference-Cited by-同舟云学术

Why proteomics is not the new genomics and the future of mass spectrometry in cell biology

Published:2016-12-12 Issue:1 Volume:216 Page:21-24
ISSN:0021-9525
Container-title:Journal of Cell Biology
language:en
Short-container-title:

Author:

Sidoli Simone¹,Kulej Katarzyna¹²,Garcia Benjamin A.¹

Affiliation:

1. Epigenetics Program, Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104

2. Division of Cancer Pathobiology, Children's Hospital of Philadelphia, Philadelphia, PA 19104

Abstract

Mass spectrometry (MS) is an essential part of the cell biologist’s proteomics toolkit, allowing analyses at molecular and system-wide scales. However, proteomics still lag behind genomics in popularity and ease of use. We discuss key differences between MS-based -omics and other booming -omics technologies and highlight what we view as the future of MS and its role in our increasingly deep understanding of cell biology.

Funder

National Institutes of Health

Publisher

Rockefeller University Press

Subject

Cell Biology

Link

http://rupress.org/jcb/article-pdf/216/1/21/1374954/jcb_201612010.pdf

Reference14 articles.

1. Intraoperative tissue identification using rapid evaporative ionization mass spectrometry;Balog;Sci. Transl. Med.,2013

2. Detection Technologies. Ambient mass spectrometry;Cooks;Science.,2006

3. The in vivo phosphorylation sites in multiple isoforms of amphiphysin I from rat brain nerve terminals;Craft;Mol. Cell. Proteomics.,2008