BRAG about (s)lots-Reference-Cited by-同舟云学术

BRAG about (s)lots

Published:2023-11-08 Issue:12 Volume:222 Page:
ISSN:0021-9525
Container-title:Journal of Cell Biology
language:en
Short-container-title:

Author:

Brown Joshua C.¹²^ORCID,Hell Johannes W.³^ORCID,Gerges Nashaat Z.⁴

Affiliation:

1. Brain Stimulation Mechanisms Laboratory, McLean Hospital 1 Division of Depression and Anxiety Disorders, , Belmont, MA, USA

2. Harvard Medical School 2 Department of Psychiatry, , Boston, MA, USA

3. School of Medicine, University of California, Davis 3 Department of Pharmacology, , Davis, CA, USA

4. School of Pharmacy, Medical College of Wisconsin 4 Biopharmaceutical Sciences Department, , Milwaukee, WI, USA

Abstract

Mutations in IQSEC2/BRAG1 cause intellectual dysfunction by impairing ARF-GEF activity and long-term depression. In this issue, Bai et al. (https://doi.org/10.1083/jcb.202307117) discover how constitutive ARF-GEF activity is regulated by a closed conformation which opens in the presence of Ca2+. Two known pathogenic mutations cause “leaky” autoinhibition with reduced synaptic dynamic range and impaired cognitive performance.

Funder

Brain & Behavior Research Foundation

Department of Defense

National Institutes of Health

Publisher

Rockefeller University Press

Subject

Cell Biology

Link

https://rupress.org/jcb/article-pdf/doi/10.1083/jcb.202310023/1920713/jcb_202310023.pdf

Reference12 articles.

1. Molecular Insights into IQSEC2 Disease

2. Bidirectional regulation of synaptic transmission by BRAG1/IQSEC2 and its requirement in long-term depression

3. BRAG1/IQSEC2 as a regulator of small GTPase-dependent trafficking

4. Arf6-GEF BRAG1 Regulates JNK-Mediated Synaptic Removal of GluA1-Containing AMPA Receptors: A New Mechanism for Nonsyndromic X-Linked Mental Disorder

5. Synaptic AMPA Receptor Exchange Maintains Bidirectional Plasticity