Mitochondrial sites of contact with the nucleus-Reference-Cited by-同舟云学术

Mitochondrial sites of contact with the nucleus

Published:2024-04-26 Issue:6 Volume:223 Page:
ISSN:0021-9525
Container-title:Journal of Cell Biology
language:en
Short-container-title:

Author:

Campanella Michelangelo¹²³^ORCID,Kannan Brindha¹^ORCID

Affiliation:

1. William Harvey Research Institute, Queen Mary University of London 1 , London, UK

2. Institute Gustave Roussy 2 , Villejuif, France

3. University of Padua 3 Department of Biomedical Science, , Padua, Italy

Abstract

Membrane contact sites (MCS) between mitochondria and the nucleus have been recently described. Termed nucleus associated mitochondria (NAM), they prime the expression of genes required for cellular resistance to stressors, thus offering a tethering mechanism for homeostatic communication. Here, we discuss the composition of NAM and their physiological and pathological significance.

Funder

European Research Council

Fondation ARC pour la Recherche sur le Cancer

Barts Charity

Biotechnology and Biological Sciences Research Council

Italian Association for Cancer Research

Research Projects of National Relevance

Publisher

Rockefeller University Press

Link

https://rupress.org/jcb/article-pdf/doi/10.1083/jcb.202305010/1927645/jcb_202305010.pdf

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5. TSPO interacts with VDAC1 and triggers a ROS-mediated inhibition of mitochondrial quality control