Affiliation:
1. University of Texas Southwestern Medical Center 1 Department of Pharmacology, , Dallas, TX, USA
Abstract
In this issue, the discovery by Yang et al. (https://doi.org/10.1083/jcb.202308013) that folded WW domains of YAP1 and other proteins bind to Impα introduces a new class of globular NLS, contrasting with the extensively studied linear NLS motifs. This finding underscores the versatility of importins in recognizing their cargo proteins.
Funder
National Institute of General Medical Sciences
Welch Foundation
Alfred and Mabel Gilman Chair in Molecular Pharmacology
Eugene McDermott Scholar in Biomedical Research
Publisher
Rockefeller University Press