Histone H1 phosphorylation is associated with transcription by RNA polymerases I and II-Reference-Cited by-同舟云学术

Histone H1 phosphorylation is associated with transcription by RNA polymerases I and II

Published:2010-05-03 Issue:3 Volume:189 Page:407-415
ISSN:1540-8140
Container-title:Journal of Cell Biology
language:en
Short-container-title:

Author:

Zheng Yupeng¹,John Sam²,Pesavento James J.¹,Schultz-Norton Jennifer R.¹,Schiltz R. Louis²,Baek Sonjoon²,Nardulli Ann M.¹,Hager Gordon L.²,Kelleher Neil L.¹¹,Mizzen Craig A.¹¹

Affiliation:

1. Department of Cell and Developmental Biology, Department of Chemistry, Department of Molecular and Integrative Physiology, and Institute for Genomic Biology, University of Illinois at Urbana-Champaign, Urbana, IL 61801

2. Laboratory of Receptor Biology and Gene Expression, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892

Abstract

Histone H1 phosphorylation affects chromatin condensation and function, but little is known about how specific phosphorylations impact the function of H1 variants in higher eukaryotes. In this study, we show that specific sites in H1.2 and H1.4 of human cells are phosphorylated only during mitosis or during both mitosis and interphase. Antisera generated to individual H1.2/H1.4 interphase phosphorylations reveal that they are distributed throughout nuclei and enriched in nucleoli. Moreover, interphase phosphorylated H1.4 is enriched at active 45S preribosomal RNA gene promoters and is rapidly induced at steroid hormone response elements by hormone treatment. Our results imply that site-specific interphase H1 phosphorylation facilitates transcription by RNA polymerases I and II and has an unanticipated function in ribosome biogenesis and control of cell growth. Differences in the numbers, structure, and locations of interphase phosphorylation sites may contribute to the functional diversity of H1 variants.

Publisher

Rockefeller University Press

Subject

Cell Biology

Link

http://rupress.org/jcb/article-pdf/189/3/407/1346809/jcb_201001148.pdf

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