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Tiny dancers

Published:2002-07-08 Issue:1 Volume:158 Page:17-21
ISSN:1540-8140
Container-title:Journal of Cell Biology
language:en
Short-container-title:

Author:

Smyth Susan S.¹,Patterson Cam¹²

Affiliation:

1. Department of Medicine (Cardiology) and The Carolina Cardiovascular Biology Center, The University of North Carolina, Chapel Hill, NC 27599

2. Department of Cell and Developmental Biology and Department of Pharmacology, The University of North Carolina, Chapel Hill, NC 27599

Abstract

A vital step in growth factor–driven angiogenesis is the coordinated engagement of endothelial integrins with the extracellular matrix. The molecular mechanisms that partner growth factors and integrins are being elucidated, revealing an intricate interaction of surface receptors and their signaling pathways.

Publisher

Rockefeller University Press

Subject

Cell Biology

Link

http://rupress.org/jcb/article-pdf/158/1/17/1304286/jcb158117.pdf

Reference41 articles.

1. Extensive Vasculogenesis, Angiogenesis, and Organogenesis Precede Lethality in Mice Lacking All αv Integrins

2. Platelet-derived Growth Factor Receptor β and Vascular Endothelial Growth Factor Receptor 2 Bind to the β3Integrin through Its Extracellular Domain

3. Thrombospondins as matricellular modulators of cell function

4. Requirement of Vascular Integrin α v β 3 for Angiogenesis

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