Nonrandom template segregation: A way to break the symmetry of stem cells-Reference-Cited by-同舟云学术

Nonrandom template segregation: A way to break the symmetry of stem cells

Published:2013-10-14 Issue:1 Volume:203 Page:7-9
ISSN:1540-8140
Container-title:Journal of Cell Biology
language:en
Short-container-title:

Author:

Yamashita Yukiko M.¹¹

Affiliation:

1. Life Sciences Institute and Department of Cell and Developmental Biology, University of Michigan, Ann Arbor, MI 48109

Abstract

Whether DNA segregates in a biased way has been a subject of intense controversy and debate. Although highly provocative in its biological implications, if true, technical problems have limited researchers from drawing firm conclusions from the data. Elabd et al. (2013. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201307110/DC1) now show a high frequency of nonrandom template segregation during differentiation of embryonic stem cells using rigorous experimentation and implicate the methyltransferase Dnmt3 as a key regulator of this process.

Publisher

Rockefeller University Press

Subject

Cell Biology

Link

http://rupress.org/jcb/article-pdf/203/1/7/1361788/jcb_201308110.pdf

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4. DNA template strand sequencing of single-cells maps genomic rearrangements at high resolution;Falconer;Nat. Methods.,2012

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