Caspase Recruitment Domain (Card-Dependent) Cytoplasmic Filaments Mediate Bcl10-Induced Nf-κb Activation

Author:

Guiet Chantal1,Vito Pasquale1

Affiliation:

1. Basel Institute for Immunology, Postfach CH-4005, Basel, Switzerland

Abstract

Mucosa-associated lymphoid tissue (MALT) lymphomas are associated with overexpression and constitutive activity of bcl10, a caspase recruitment domain (CARD)-containing protein that activates NF-κB. Here, we show that arrangement of overexpressed bcl10 protein in cytoplasmic filaments is essential for recruitment of signal transducer molecules-involved NF-κB activation. We also show that cytoskeleton elements regulate bcl10 signaling. Thus, organized assemblage of proteins in ordered structures linked to the cytoskeleton network may represent a general mechanism for intracellular signaling.

Publisher

Rockefeller University Press

Subject

Cell Biology

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