Matrix nanotopography as a regulator of cell function

Author:

Kim Deok-Ho1,Provenzano Paolo P.2,Smith Chris L.3,Levchenko Andre3

Affiliation:

1. Department of Bioengineering, University of Washington, Seattle, WA 98195

2. Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109

3. Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD 21218

Abstract

The architecture of the extracellular matrix (ECM) directs cell behavior by providing spatial and mechanical cues to which cells respond. In addition to soluble chemical factors, physical interactions between the cell and ECM regulate primary cell processes, including differentiation, migration, and proliferation. Advances in microtechnology and, more recently, nanotechnology provide a powerful means to study the influence of the ECM on cell behavior. By recapitulating local architectures that cells encounter in vivo, we can elucidate and dissect the fundamental signal transduction pathways that control cell behavior in critical developmental, physiological, and pathological processes.

Publisher

Rockefeller University Press

Subject

Cell Biology

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