An AIF orthologue regulates apoptosis in yeast-Reference-Cited by-同舟云学术

An AIF orthologue regulates apoptosis in yeast

Published:2004-09-20 Issue:7 Volume:166 Page:969-974
ISSN:1540-8140
Container-title:Journal of Cell Biology
language:en
Short-container-title:

Author:

Wissing Silke¹,Ludovico Paula²,Herker Eva¹,Büttner Sabrina¹,Engelhardt Silvia M.¹,Decker Thorsten¹,Link Alexander¹,Proksch Astrid¹,Rodrigues Fernando²,Corte-Real Manuela³,Fröhlich Kai-Uwe⁴,Manns Joachim⁵,Candé Céline⁶,Sigrist Stephan J.⁷,Kroemer Guido⁶,Madeo Frank¹

Affiliation:

1. Institute for Physiological Chemistry, University of Tübingen, 72076 Tübingen, Germany

2. Life and Health Sciences Research Institute, Health Sciences School

3. Department of Biology, School of Sciences, University of Minho, 4710-057 Braga, Portugal

4. IMBM, University of Graz, 8010 Graz, Austria

5. Department of Internal Medicine I, University of Tübingen, 72076 Tübingen, Germany

6. CNRS-UMR8125, Institut Gustave Roussy, F-94805 Villejuif, France

7. European Neuroscience Institute Göttingen, Max-Planck-Society, 37073 Göttingen, Germany

Abstract

Apoptosis-inducing factor (AIF), a key regulator of cell death, is essential for normal mammalian development and participates in pathological apoptosis. The proapoptotic nature of AIF and its mode of action are controversial. Here, we show that the yeast AIF homologue Ynr074cp controls yeast apoptosis. Similar to mammalian AIF, Ynr074cp is located in mitochondria and translocates to the nucleus of yeast cells in response to apoptotic stimuli. Purified Ynr074cp degrades yeast nuclei and plasmid DNA. YNR074C disruption rescues yeast cells from oxygen stress and delays age-induced apoptosis. Conversely, overexpression of Ynr074cp strongly stimulates apoptotic cell death induced by hydrogen peroxide and this effect is attenuated by disruption of cyclophilin A or the yeast caspase YCA1. We conclude that Ynr074cp is a cell death effector in yeast and rename it AIF-1 (Aif1p, gene AIF1).

Publisher

Rockefeller University Press

Subject

Cell Biology

Link

http://rupress.org/jcb/article-pdf/166/7/969/1315411/jcb1667969.pdf

Reference29 articles.

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4. AIF and cyclophilin A cooperate in apoptosis-associated chromatinolysis

5. Apoptosis-inducing factor is involved in the regulation of caspase-independent neuronal cell death

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