Affiliation:
1. The Salk Institute for Biological Studies, La Jolla, CA
Abstract
What causes inflammation in age-related neurodegenerative diseases remains a mystery. Sliter et al. (2018. Nature. https://doi.org/10.1038/s41586-018-0448-9) show that, when damaged mitochondria cannot be removed by mitophagy, stress from exercise or mitochondrial DNA mutations activates the proinflammatory cGAS–STING pathway that may contribute to Parkinson’s disease.
Funder
National Institutes of Health
Hewitt Foundation
Publisher
Rockefeller University Press
Cited by
43 articles.
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