Affiliation:
1. Department of Physics and Astronomy, University of Sheffield, Sheffield, UK
Abstract
How the nucleus affects cell polarity and migration is unclear. In this issue, Graham et al. (2018. J. Cell Biol. https://doi.org/10.1083/jcb.201706097) show that enucleated cells polarize and migrate in two but not three dimensions and propose that the nucleus is a necessary component of the molecular clutch regulating normal mechanical responses.
Funder
Engineering and Physical Sciences Research Council
Publisher
Rockefeller University Press
Cited by
3 articles.
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