Modeling network dynamics-Reference-Cited by-同舟云学术

Modeling network dynamics

Published:2003-05-12 Issue:3 Volume:161 Page:471-476
ISSN:1540-8140
Container-title:Journal of Cell Biology
language:en
Short-container-title:

Author:

Vilar José M.G.¹,Guet Călin C.¹²,Leibler Stanislas¹

Affiliation:

1. The Rockefeller University, New York, NY 10021

2. Department of Molecular Biology, Princeton University, Princeton, NJ 08544

Abstract

We use the lac operon in Escherichia coli as a prototype system to illustrate the current state, applicability, and limitations of modeling the dynamics of cellular networks. We integrate three different levels of description (molecular, cellular, and that of cell population) into a single model, which seems to capture many experimental aspects of the system.

Publisher

Rockefeller University Press

Subject

Cell Biology

Link

http://rupress.org/jcb/article-pdf/161/3/471/1308050/jcb1613471.pdf

Reference26 articles.

1. Investigating Autocatalytic Gene Expression Systems through Mechanistic Modeling

2. INHIBITION BY GLUCOSE OF THE INDUCED SYNTHESIS OF THE β-GALACTOSIDE-ENZYME SYSTEM OF ESCHERICHIA COLI . ANALYSIS OF MAINTENANCE

3. ANALYSIS OF THE DIFFERENTIATION AND OF THE HETEROGENEITY WITHIN A POPULATION OF ESCHERICHIA COLI UNDERGOING INDUCED β-GALACTOSIDASE SYNTHESIS

4. On physiological multiplicity and population heterogeneity of biological systems

5. Statistical Fluctuations in Autocatalytic Reactions

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