Wnt-5a inhibits the canonical Wnt pathway by promoting GSK-3–independent β-catenin degradation-Reference-Cited by-同舟云学术

Wnt-5a inhibits the canonical Wnt pathway by promoting GSK-3–independent β-catenin degradation

Published:2003-09-01 Issue:5 Volume:162 Page:899-908
ISSN:1540-8140
Container-title:Journal of Cell Biology
language:en
Short-container-title:

Author:

Topol Lilia¹,Jiang Xueyuan¹,Choi Hosoon¹,Garrett-Beal Lisa¹,Carolan Peter J.¹,Yang Yingzi¹

Affiliation:

1. Genetic Disease Research Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892

Abstract

Wnts are secreted signaling molecules that can transduce their signals through several different pathways. Wnt-5a is considered a noncanonical Wnt as it does not signal by stabilizing β-catenin in many biological systems. We have uncovered a new noncanonical pathway through which Wnt-5a antagonizes the canonical Wnt pathway by promoting the degradation of β-catenin. This pathway is Siah2 and APC dependent, but GSK-3 and β-TrCP independent. Furthermore, we provide evidence that Wnt-5a also acts in vivo to promote β-catenin degradation in regulating mammalian limb development and possibly in suppressing tumor formation.

Publisher

Rockefeller University Press

Subject

Cell Biology

Link

http://rupress.org/jcb/article-pdf/162/5/899/1310052/jcb1625899.pdf

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